our achievements
- Set-up and validation of Oracle-based LIMS database Madmax for storage of raw and normalised microarray datasets
- Completion of several larger mouse intervention studies including the “Leiden“ study with genetically sensitised ApoE3Leiden mice
- Microarray analysis of several large mouse and human studies using the improved standardised microarray pipeline with normalisation procedure and quality control
- Metabolomics analysis of all several large studies (Leiden study, Human Pilot study)
- Identification of several gene polymorphisms associated with the HYPLIP
sensitising genotype
- Improvement of microarray data analysis by combining several bioinformatics and pathway mining programs
- Employment of the FIAF-transgenic mouse as proof-of-principal mouse model for nutrigenomics research
- First identification of PPAR a as the hepatic sensor for dietary fatty acids and further understanding of the PPAR a -dependent transcriptome in liver and intestine
- Design and production of the NUGO mouse and human Affymetrix oligonucleotide microarray with improved probe sets costing 30% less than the 2.0 Affymetrix array