profile: prof. dr. m. müller
Prof. Dr. Michael Müller is Scientific Director of the Nutrigenomics Consortium and full professor of Nutrition, Metabolism and Genomics (NMG) and head of the NMG-group within the Division of Human Nutrition at Wageningen University, the Netherlands. He studied chemistry at the University of Freiburg/Germany and performed a PhD thesis in Biochemistry on “Liver drug transporters”. After a 5-year period as post-doc working on liver transporter proteins at the German Cancer Research Centre in Heidelberg/Germany, he moved in 1994 to the University of Groningen (Netherlands). There he was head (1998 as associate professor) of the “Transporter/Bile physiology group”. He is (co)author of more then 100 peer-reviewed publications. The NMG group consists currently of 1 associate professor, 3 assistant professors, 6 postdocs, 10 PhD students, 7 technicians and 2 bioinformaticians. The group studies the molecular mechanisms behind effects of food components (in particular fatty acids) on gene expression and homeostasis and the role of “two hits” in the pathophysiology of metabolic stress and metabolic syndrome.
He is scientific director of the Dutch “Nutrigenomics Consortium” (21 Million €; 2004-2009; around 60 scientists) within the Wageningen Centre of Food Sciences (WCFS). He is also board member of the Network of Excellence in Nutrigenomics “NUGO” within the EU program KP6.
memberships/awards
Currently, Prof. Müller is a member of the editorial boards of several journals, i.e. the AACR-jounal "Molecular Cancer Therapeutics", the "European Journal o Nutrition". the “World Journal of Gastroenterology”, and the “Journal of Oncology”. He is also a member of the “Faculty of 1000” (Biology/Physiology). He has been part of the organizational committees of several international scientific meetings, a.o. of the first national Nutrigenomics Conference, Wageningen (2001), the International Nutrigenomics Conference 2003, the first International “Personalized nutrition conference (2005), the second NUGO week (2005) and the 10th FENS nutrition conference in Paris (2007). Prof. Müller is also a Network Board Member of the EU network of excellence “Nutrigenomics” (NuGO).
publications
Key publications in peer-reviewed journals:
1. Müller M, Kersten S. Nutrigenomics: Goals and Perspectives. Nature Reviews Genetics 2003, 4, 315-22.
2. Patsouris D, Mandard S, Voshol PJ, Escher P, Tan NS, Havekes LM, Koenig W, Marz W, Tafuri S, Wahli W, Müller M, Kersten S. PPARalpha governs glycerol metabolism. J Clin Invest. 2004;114:94-103.
3. Mandard S, Zandbergen F, Tan NS, Escher P, Patsouris D, Koenig W, Kleemann R, Bakker A, Veenman F, Wahli W, Müller M, Kersten S. The direct peroxisome proliferator-activated receptor target fasting-induced adipose factor (FIAF/PGAR/ANGPTL4) is present in blood plasma as a truncatedprotein that is increased by fenofibrate treatment. J Biol Chem. 2004;279:34411-20.
4. Afman L, Müller M. Nutrigenomics: From Molecular Nutrition to the Prevention of Disease. J Am Diet Association 2006; 106: 569-576.
5. Patsouris D, Reddy JK, Müller M, Kersten S PPAR{alpha} mediates the effects of high fat diet on hepatic gene expression. Endocrinology 2006;147:1508-16.
In 2003-2006 21 Publications in peer-reviewed journals
publications before 2003 can be accessed here.