profile: dr. r. van der meer
Dr. Roelof van der Meer leads the Nutrition group of NIZO food research since 1989 and became Senior Scientist Nutrition in 2004. He studied biochemistry (cum laude) at the University of Amsterdam, and received a PhD degree in 1979 for his thesis on control of hepatic metabolism. Subsequently, he joined NIZO food research and specialized in nutritional biochemistry. His major interest is the relation between diet and intestinal health. He is (part-time) associate professor at the University of Groningen since 1993. He is project leader at WCFS since 1998 for the projects “Dietary modulation of colon cancer risk” and “Dietary modulation of intestinal infections”. His combined nutritional and biochemical research has a strong mechanistic approach and is published in over 100 peer-reviewed papers. The Hirsch-index of this output is 30. He is (co)author of about 20 book chapters and (co)inventor on 6 patent applications.
publications
15 Publications in peer-reviewed journals
2003-2006
1. Bovee-Oudenhoven IM, ten Bruggencate SJ, Lettink-Wissink ML, Van der Meer R. Dietary fructo-oligosaccharides and lactulose inhibit intestinal colonisation but stimulate translocation of salmonella in rats. Gut. 2003; 52(11):1572-8.
2. Pierre F, Tache S, Petit CR, Van der Meer R, Corpet DE. Meat and cancer: haemoglobin and haemin in a low-calcium diet promote colorectal carcinogenesis at the aberrant crypt stage in rats. Carcinogenesis. 2003; 24(10):1683-90.
3. Bovee-Oudenhoven IM, Lettink-Wissink ML, Van Doesburg W, Witteman BJ, Van der Meer R. Diarrhea caused by enterotoxigenic Escherichia coli infection of humans is inhibited by dietary calcium. Gastroenterology. 2003; 125(2):469-76.
4. Ten Bruggencate SJ, Bovee-Oudenhoven IM, Lettink-Wissink ML, Van der Meer R. Dietary fructo-oligosaccharides dose-dependently increase translocation of salmonella in rats. J Nutr. 2003; 133(7):2313-8.
5. Van Der Meer-Van Kraaij C, Van Lieshout EM, Kramer E, Van der Meer R, Keijer J. Mucosal pentraxin (Mptx), a novel rat gene 10-fold down-regulated in colon by dietary heme. FASEB J. 2003; 17(10):1277-85.
publications 2004
6. Van Lieshout EM, Van Doesburg W, Van der Meer R. Real-time PCR of host DNA in feces to study differential exfoliation of colonocytes between rats and humans. Scand J Gastroenterol. 2004; 39(9):852-7
7. Pierre F, Freeman A, Tache S, Van der Meer R, Corpet DE. Beef meat and blood sausage promote the formation of azoxymethane-induced mucin-depleted foci and aberrant crypt foci in rat colons. J Nutr. 2004; 134(10):2711-6.
8. Ten Bruggencate SJ, Bovee-Oudenhoven IM, Lettink-Wissink ML, Katan MB, Van der Meer R. Dietary fructo-oligosaccharides and inulin decrease resistance of rats to salmonella: protective role of calcium. Gut. 2004; 53(4):530-5.
publications 2005
9. Pretzer G, Snel J, Molenaar D, Wiersma A, Bron PA, Lambert J, de Vos WM, Van der Meer R, Smits MA, Kleerebezem M. Biodiversity-based identification and functional characterization of the mannose-specific adhesin of Lactobacillus plantarum. J Bacteriol. 2005 Sep;187(17):6128-36.
10. de Vogel J, Jonker-Termont DS, Katan MB, Van der Meer R. Natural chlorophyll but not chlorophyllin prevents heme-induced cytotoxic and hyperproliferative effects in rat colon. J Nutr. 2005; 135(8):1995-2000.
11. Ten Bruggencate SJ, Bovee-Oudenhoven IM, Lettink-Wissink ML, Van der Meer R. Dietary fructooligosaccharides increase intestinal permeability in rats. J Nutr. 2005; 135(4):837-42.
12. de Vogel J, Jonker-Termont DS, van Lieshout EM, Katan MB, Van der Meer R. Green vegetables, red meat and colon cancer: chlorophyll prevents the cytotoxic and hyperproliferative effects of haem in rat colon. Carcinogenesis. 2005; 26(2):387-93.
13. van der Meer-van Kraaij C, Kramer E, Jonker-Termont D, Katan MB, Van der Meer R, Keijer J. Differential gene expression in rat colon by dietary heme and calcium. Carcinogenesis. 2005; 26(1):73-9.
publications 2006
14. Balder HF, Vogel J, Jansen MC, Weijenberg MP, van den Brandt PA, Westenbrink S, Van der Meer R, Goldbohm RA. Heme and chlorophyll intake and risk of colorectal cancer in the Netherlands cohort study. Cancer Epidemiol Biomarkers Prev. 2006 Apr;15(4):717-25.
15. Ten Bruggencate SJ, Bovee-Oudenhoven IM, Lettink-Wissink ML, Katan MB, Van der Meer R. Dietary fructooligosaccharides affect intestinal barrier function in healthy men. J Nutr. 2006 Jan;136(1):70-4.