publications archive
2008
Peer-reviewed papers
- Bouwens M, Afman LA, Müller M
Activation of peroxisome proliferator-activated receptor alpha in human peripheral blood mononuclear cells reveals an individual response
BMC Genomics. 2008 Jun 2;9(1):262 - De Wilde J, Mohren R, Van den Berg S, Boekschoten M, Willems
van Dijk K, De Groot P, Müller M, Mariman E, and Smit E (2008)
Short-term high fat-feeding results in morphological and metabolic adaptations in the skeletal muscle of C57BL/6J mice. Physiological Genomics 32, 360-369 . - De Vogel-Van den Bosch HM, De Wit NJW, Hooiveld GJEJ, Bosch-Vermeulen
H, VanderVeen JN, Houten SM, Kuipers F, Müller M, and Van der
Meer R (2008)
A cholesterol free, high-fat diet auppresses gene expression of cholesterol transporter genes in murine small intestine. American Journal of Physiology - Gastrointestinal and Liver Physiology 294, 1171-1180 . - De Vogel-van den Bosch HM, Bünger M, de Groot PJ, Bosch-Vermeulen
H, Hooiveld GJ, Müller M
PPARalpha-mediated effects of dietary lipids on intestinal barrier gene expression.
BMC Genomics 2008, 9:231 - De Wit NJW, Bosch-Vermeulen H, DeGroot PJ, Hooiveld GJE,
GrootteBromhaar MM, Jansen J, Müller M, and VanderMeer R (2008)
The role of the small intestine in the development of dietary fat-induced obesity and insulin resistance in C57BL/6J mice. BMC Medical Genomics 1, 14-0 . - Herrema H, Derks TGJ, van Dijk TH, Bloks VW, Gerding A,
Havinga R, Tietge UJF, Müller M, Smit PA, Kuipers F, Reijngoud
DJ
Disturbed Hepatic Carbohydrate Management During High Metabolic Demand in Medium-Chain Acyl-CoA Dehydrogenase (MCAD)-Deficient Mice. Hepatology 2008 Jun;47(6):1894-904 - Rahkshandehroo M, Stienstra R, Carlberg C, De Groot PJ, and
Müller M (2008)
Comprehensive analysis of PPARalpha-dependent regulation of hepatic lipid metabolism by expression profiling. PPAR research doi:10.1155/2007/26839, 0 . - Sanderson LM de Groot PJ, Hooiveld GJEJ, Koppen A, Kalkhoven
E, Müller M, Kersten S
Effect of Synthetic Dietary Triglycerides: a Novel Research Paradigm for Nutrigenomics PLOS ONE 2008 27;3(2):e1681. - Stienstra R, Duval C, Keshtkar S, van der Laak J, Kersten S,
Müller M
PPARgamma activation promotes infiltration of alternatively activated macrophages into adipose tissue. Journal of Biological Chemistry 283; 22620–22627 - Van Ommen B, Keijer J, Kleemann R, Elliott R, Drevon CA,
McArdle H, Gibney G, and Müller M (2008)
The challenges for molecular nutrition research 2: quantification of the nutritional phenotype. Genes and Nutrition 3, 4149 .
Posters
- Bragt MCE, Plat J, Mensink M, Schrauwen P, and Mensink RP
The effect of Rosiglitazone on inflammatory markers and NFkappaB-related genes in type II diabetic subjects. Keystone, 27-1-2008 . Breckenbridge, Co, USA. - De Wit N, Bosch-Vermeulen H, Oosterink E, Müller M, and Van
der Meer R
Dietary calcium does not protect against dietary fat-induced obesity and insulin resistance in C57Bl/6j mice. FASEB Summer Research Conference 2008: Molecular Mechanisms Involved in the Nutrient Control of Cellular Function, 25-7-2008 . Carefree, Arizona, USA. - Duval C, Boekschoten M, Keshtkar S, DeGroot P, Jansen J,
Roskams T, Kersten S, and Müller M
eWat failure signals the evolution of NAFLD towards NASH in the C56BL/6 dio model. Keystone, 27-1-0200 . Beckenbridge Co, USA. - Popeijus HE and Mensink RP
Human stearoyl-Coenzyme A desaturase 1 linked to insulin signalling? Keystone, 27-1-2008 . Breckenbridge, Co, USA. - Radonjic M, van Erk M, Willems van Dijk K, van de Berg S,
and Van Ommen B
Genome-wide mRNA expression analysis of high-fat induced hepatic pathophysiology in ApoE3*L mice. Systems Biology: Global Regulation of Gene Expression, 30-3-2008 . Cold Spring Harbor, USA. - Rakhshandehroo M, Müller M, and Kersten S
The PPARa dependent transcriptome in primary human hepatocytes. Symposium CIG metabolism and cancer, 3-6-2008 . Lausanne, Switzerland.
2007
Peer-reviewed papers
- Bouwens M, Afman L, and Müller M (2007)
Fasting induces changes in peripheral blood mononuclear cell gene expression profiles related to increases in fatty acid beta-oxidation. A functional role of PPAR alpha in human peripheral blood mononuclear cell. American Journal of Clinical Nutrition 86, 1515-1523 . - Bünger M, Van den Bosch HM, Van der Meijde J, Kersten S,
Hooiveld GJ, and Müller M (2007)
Genome-wide analysis of PPAR-alpha activiation in murine small intestine. Physiological Genomics 30, 192-204 . - Bünger M, Hooiveld GJ, Kersten S, and Müller M (2007)
Exploration of PPAR functions by microaray tehnology-A paradignm for nutrigenomics. Biochimica et Biophysica Acta-General Subjects 1771, 1046-1064 - Duval C, Müller M, and KerstenS. (2007)
PPAR-alpha and dyslipidemia. Biochimica et Biophysica Acta-General Subjects 1771, 961-971 . - Gaj S, VanErk A, Van Haaften RIM, and Evelo CTA (2007)
Linking microarray reporters to protein functions. BMC Genomics 8, 267 . - Lichtenstein L, Berbee JF, Van Dijk S, Blijland S, Willems
van Dijk K, Voshol PJ, Müller M, and Rensen PCN (2007)
Angptl4 up-regulates cholesterol synthesis in liver via inhibition of LPL- and HL-dependent hepatic cholesterol uptake. Arteriosclerosis Thrombosis and Vascular Biology 27, 2420-2427 . - Mandard S, Stienstra R, Escher P, Tan NS, Kim I, Gonzalez FJ,
Wahli W, Desvergne B, Müller M, and Kersten S (2007)
Glycogen synthase 2 is a novel target gene of peroxisome proliferator-activated receptors. Cellular and Molecular Life Sciences 64, 1145-1157 . - Stienstra R, Mandard S, Tan NS, Wahli W, Trautwein C,
RichardsonT.A., Lichtenauer-Kaligis E, Kersten S, and Müller M
(2007)
The interleukin-1 receptor antagonist is a direct target gene of PPARalpha in liver. Journal of Hepatology 46, 869-877 . - Stienstra R, Mandard S, Patsouris D, Maass C, Kersten S, and
Müller M (2007)
Peroxisome proliferator-activated receptor alpha protects against obesity-induced hepatic inflammation. Endocrinology 148, 2753-2763. - Van den Bosch HM, Bünger M, De Groot PJ, Van der Meijde J,
Hooiveld GJ, and Müller M (2007)
Gene expression of transporters and phase I/II metabolic enzymes in murine small intestine during fasting. BMC Genomics 8, 267
Invited lectures at international conferences
- Kersten S
Role of PPARalpha in fatty acid sensing. 10th FENS conference, 13-7-2007 . Paris, France. - Kersten S
The role of PPARs as fatty acid sensors controlling metabolism and inflammation. Fall meeting Dutch Society for Gastroenterology, 1-10-2007 . Veldhoven, the Netherlands. - Kersten S
Regulation of metabolism by PPARalpha and Angiopoietin-like protein4. Brigham and Women's Hospital, Harvard Medical School, 1-10-2007 . Harvard, USA. - Kersten S
Nutrigenomics. Nutrition Conference 2007, 12-12-2007 . Bangkok, Thailand. - Kersten S
Transgenic mice in nutrigenomics research. Masterclass Nutrigenomics, Wageningen University, 11-11-2007 . Wageningen, the Netherlands. - Kersten S
Regulation of metabolism by PPARalpha and Angiopoitein-like protein 4. Centre Intqgrative de Gqnomique, Universitq de Lausanne, 11-11-2007 . Lausanne, Switzerland. - Kersten S
Angiopoetin-like proteins in glucose and lipid metabolism, from mice to men. 3rd annual HDL symposium on Diabetic Sylipidemia, 9-2-2007 . Rotterdam, the Netherlands. - Mensink RP
Health aspects of trans fatty acids. NZO/EDA Expert meeting on TFA & CLA, 4-5-2007 . Amsterdam, The Netherlands. - Mensink RP
Defining the optimal fatty acid profile for the human diet: the role of saturated fatty acids. Canadian Nutrition Congress, 21-6-2007 . Winnipeg, Canada. - Mensink RP
Voeding, cholesterol en hart- en vaatziekten. Chemische kring, Eindhoven, The Netherlands. - Mensink RP
Dairy products and their role in the metabolic syndrome. Campina Science Day "Dairy and the Circle of Life", Rotterdam. - Müller M
State of the art lecture on Nutrigenomics. German Nutrition Congress, 9-3-2007 . Halle, Germany. - Müller M
Nutrigenomics and system biology. NUGO Symposium "The Quantification of Health", 18-5-2007 . Cork, Ireland. - Müller M
Gene regulation by fatty acids. Seefeld Proteomics Conference, 31-1-2007 . Seefeld, Austria. - Müller M
Applications of microarray analysis in hepatology. Basic School of Hepatology of the European Association for Study of the Liver (EASL). Course 2: Cell signaling in the liver, 4-2-2007 . Lisbon, Portugal. - Müller M
Transcriptiomics applications in Nutrigenomics. 10th FENS Nutrition, 13-7-2007 . Paris, France. - Müller M
Systems biology of fatty acid sensing. Annual NUGO conference, 21-9-2007 . Oslo, Norway. - Müller M
Nutrigenomics. Individualized Medicine in Complex Diseases, 23-6-2007 . Regensburg, Germany. - Müller M
Genomics for robust cows. ID-Lelystad Symposium "Nutrigenomics", 8-6-2007 . Lelystad, the Netherlands. - Müller M
The NUGO proof-of-principle study. NUGO meeting, 17-7-2007 . Mnnich, Germany. - Van Ommen B
Systems Biology in the nutrition and health relationship. University of Graz symposium on nutrition and antioxidants, 17-10-2007 . Graz, Oostenrijk. - Van Ommen B
Nutrigenomics as key driver for nutrition and health relationship. 1st Varna Nutrigenomics Conference, 18-10-2007 . Varna, Bulgarije. - Van Ommen B
The targeted plasma proteome in personalized health and nutrition. XMAP symposium, Amsterdam, 8-10-2007 . Amsterdam, Nederland. - Van Ommen B
How can NuGO revolutionize human nutrition research using "omics" approaches? NuGO Bioethics workshop, Oslo, 18-9-2007 . Oslo, Noorwegen. - Van Ommen B
Can nutrigenomics lead us to prevention of obesity? Oresund Obesity conference, Kopenhagen, 2-10-2007 . Kopenhagen, Denemarken. - Van Ommen B
Nutrigenomics and nutritional Systems biology in Europe. Nutrigenomics Seminar, Kuopio University, 3-12-2007 . Kuopio, Finland. - Van Ommen B
Metabolomics in the quantification of the nutrition and health relationship. Workshop on nutritional metabolomics, 12-12-2007 . Clermont-Ferrand, Frankrijk. - Van Ommen B
Metabolomics in the quantification of the nutrition and health relationship. Unilever symposium on nutritional metabolomics, 15-11-2007 . Vlaardingen, Nederland. - Van Ommen B
Pharmacogenomics and nutrition: Insights in disease prevention. Novo Nordisk Diabetes Dialogue conference, 26-10-2007 . Lisbon, Portugal. - Van Ommen B
Metabolomics in nutrition research. Friedman Nutrition Symposium, 30-10-2007 . Boston, USA. - Van Ommen B
Perspectives in personalised nutrition in research and industrial applications. Bioinnovativ Munich, 18-2-2007 . Munchen, Duitsland. - Van Ommen B
Nutritional systems biology. Molecular Medicine Congress, 24-3-2007 . Istanbul, Turkey. - Van Ommen B
Nutritional metabolomics in the quantification of health. Conference " What we are and what we eat", Charlotte, 16-4-2007 . Charlotte, USA. - Van Ommen B
Voeding van Topkwaliteit. Natuurkundig gezelschap Assen, 9-1-2007 . Assen, Nederland. - Van Ommen B
Life Sciences in 2012? Hogeschool Utrecht workshop, 9-10-2007 . Utrecht, Nederland. - Van Ommen B
Nutrigenomics, voeding voor jouw genetische profiel. Studium Generale, Utrecht, 12-11-2007 . Utrecht, Nederland. - Van Ommen B
Metabolism as Key in nutrition research. Northern light conference, Waterloo, 22-6-2007 . Waterloo, Canada. - Van Ommen B
Nutritional Systems Biology. 10th European Nutrition Conference, 12-7-2007 . Paris, France. - Van Ommen B
Nutrigenomics - an overview. Leatherhead nutrigenomics symposium, London, 11-9-2007 . London, UK. - Van Ommen B
New challenges for molecular nutrition research. EuroBio, Krakow, 26-4-2007 . Krakow, Polen. - Van Ommen B
The nutritional phenotype database. Symposium "The quantification of health", Cork, 18-5-2007 . Cork, Ireland. - Van Ommen B
Nutritional systems biology from theory to practice. Cambridge Healthtech Institute Beyond Genome Conference, San Francisco, 20-6-2007 . San Francisco, USA.
Posters
- De Groot PJ, Gavai A, Lin K, Neerincx P, Hooiveld G,
Leunissen JAM, and Müller M
Tools that NuGO makes available to you to analyse your NuGO microarrays. NuGO week, Oslo, Norway. - De Wilde J, Mohren R, Mariman E, and Smit E
A high fat/low carbohydrate diet down-regulates genes involved in synthesis, processing and storage of fatty acids in skeletal muscle of mice. - Rahkshandehroo M
The role of PPARalpha in the human liver. NUGO week. Oslo, Norway. - Sanderson L
The effects of dietary fatty acids on hepatic gene expression are almost entirely mediated by PPARalpha. Keystone symposium: Nuclear Receptor Pathways to Metabolic Regulation. Steamboat Springs, Colorado , USA. - Thissen U, Wopereis S, Van Den Berg SAA, Bobeldijk I,
Kleemann R, Kooistra T, Willems vanD ijk K, Van Ommen B, and
Smilde A.K
Relating functional genomic data to phenotypes: an improved approach for structured data. NuGO week. Oslo, Norway. - Thissen, U.; Rubingh, C.;Van Erk, M.J.
Statistical data quality control in the light of biological relevance. NuGO week. Oslo, Norway.
2006
Peer-reviewed papers
- Afman L and Müller M (2006)
Nutrigenomics: From Molecular Nutrition to Prevention of Disease. Journal of the American Dietetic Association 106, 569-576 . - Henneman P, Schaap GS, Havekes LM, Rensen PCN, Frants RR, VanTol A, Hattori H, Smelt AHM, and WillemsvanDijk K (2006)
Plasma apoAV levels are markedly elevated in severe hypertriglyceridemia and positively correlated with the APOA5 S19W polymorphism. Atherosclerosis 193, 120-134 .
Invited lectures at international conferences
- Afman L
Nutrigenomics - From stressed mice to prevention of disease. ALCUEFOOD nutrigenomics workshop, 13-11-2006 . Lisbon, Portugal. - Müller M
Transciptomics analysis of fatty acid dependent gene regulation. Masterclass Nutrigenomics, 19-5-2006 . Maastricht, the Netherlands. - Müller M
Nutrigenomics: From stressed mice to healthy humans. GUIDE-UMCG Summer meeting, 29-6-2006 . Groningen, the Netherlands. - Müller M
Nutrigenomics: Scientific basis for individuality - challenges and (un)certainties. CSG conference "Genomics & Society: towards a socially robust science, 20-4-2006 . Amsterdam, the Netherlands. - Müller M
Smart foods: Die young as late as possible. Nutrigenomics: From molecular nutrition to prevention of disease. Food for the healthy elderly, 27-1-2006 . Amsterdam, the Netherlands. - Müller M
Nutrigenomics: from stressed mice to healthy humans. Unilever, Vlaardingen, the Netherlands. - Müller M
Nutrigenomics; from stressed mice to healthy humans. DSM Nutritional Products, 3-4-2006 . Basel, Switzerland. - Müller M
Nutrigenomics. Karolinska PhD Course, 16-6-2006 . Stockholm, Sweden. - Müller M
Nutrigenomics: the scientific background. Annual meeting Dutch Nutrition Society, 19-10-2006 . Utrecht, The Netherlands. - Müller M
Hepatic nuclear receptors and steatosis. Autumn meeting Dutch Society of Hepatology, 5-10-2006 . Veldhoven, the Netherlands. - Müller M
Nutrigenomics; from stressed mice to healthy humans. DSM Nutritional Products, 3-4-2006 . Basel, Switzerland. - Müller M
Fatty acids as potent regulators of gene transciption - a Nutrigenomics approach. 4th Euro Fed Lipid Congress, 3-10-2006 . Madrid, Spain. - Müller M
Nutrigenomics - from molecular nutrition to prevention of disease. Functional food symposium, 13-10-2006 . Hongkong, China. - Müller M
Nutrition related transcriptiome data analysis - from small signals to biological meaning. Benelux Bioinformatics Conference, 18-10-2006 . Wageningen, the Netherlands. - Van Ommen B
A nutritional systems biology approach between inflammation and metabolic stress. The international conference on nutrigenomics and guth health, 1-5-2006 . Auckland, New Zealand. - Van Ommen B
Nutritional systems biology. Bioperspectives im Fokus "Food for the Future", 26-4-2006 . Potsdam, Germany. - Van Ommen B
Nutrigenomics and healthy nutrition. Vitafood International Conference, 10-5-2006 . Geneva, Switzerland. - Van Ommen B
Nutrition, disease and molecular mechanisms using omics technologies. Nutrition Society Summer Meeting, 5-7-2006 . Aberdeen, UK. - Van Ommen B
Nutritional Metabolomics in practice. Metabolomics Society 2nd Annual Conference, 29-6-2006 . Boston, USA. - Van Ommen B
From nutrition to nutrigenomics and back again. LMC symposium on nutrigenomics, 15-3-2006 . Copenhagen, Danmark. - Van Ommen B
The systems approach to personalized nutrition. Leatherhead conference on nutrigenomics, 20-2-2006 . London, UK. - Van Ommen B
Nutrigenomics and nutrional systems biology in prevention of cardiovascular disease. Unilever Corporate workshop series, 18-1-2006 . Colworth, UK. - Van Ommen B
The food and health relationship approached by nutritional systems biology. First Mage Circe Metabolic systems analysis conference, 26-3-2006 . Sabauida, Italy. - Van Ommen B
Voeding van Topkwaliteit. Diligentia maatschappij ter bevordering van de natuurkunde, 20-3-2006 . The Hague, The Netherlands. - Van Ommen B
Lipidomics in a large dietary intervention study. Joint Genome Canada - LMC workshop on nutrigenomics, 17-3-2006 . Roskilde, Danmark.
Posters
- De Groot P, Gavai A, Lin K, Lui Y, Hooiveld G, Leunissen J, and Müller M
NuGO human and mouse microarray support. The (statistical) analysis pipeline. The Third European Nutrigenomics Conference, NuGO week 2006,. Oxford, U.K. - Gavai A, De Groot P, Lin K, Lui Y, Hooiveld G, Müller M, and Leunissen J
MADMAX û Management and Analysis Database for MicroArray eXperiments. The Third European Nutrigenomics Conference, NuGO week 2006, Oxford, U.K. - De Wit N, Vermeulen H, Muller M, and Van der Meer R
Analysis of small intestinal gene expression in C57Bl/6 mice revealed a protective effect of calcium on dietary fat induced cell proliferation. Digestive Disease Week, Los Angeles, USA. - De Wit N, Vermeulen H, and Müller M
Gene expression patterns reveal biological processes that are influenced by dietary fat in small intestine of C57Bl/6 mice, developing metabolic synrome on a high fat diet. FASEB Summer Research Conferences. Tucson, USA. - De Wilde J, Mohren R, Mariman E, and Smit E
A high fat/low carbohydrate diet down-regulates genes involved in synthesis, processing and storage of fatty acids in skeletal muscle of mice. The Third European Nutrigenomics Conference, NuGO week 2006,. Oxford, U.K. - Lichtenstein L, Müller M, and Kersten S
Exploration of the fasting induced adipose factor as a marker for metabolic syndrome. NuGO PhD introduction Course. Munich, Germany. - Lichtenstein L, Müller M, and Kersten S
Exploration of the fasting induced adipose factor as a marker for metabolic syndrome. NuGO PhD introduction Course,. Munich, Germany. - Lichtenstein L, Berbe J, Rensen P, Müller M, and Kersten S
Regulation of plasma lipoprotein metabolism by ANGPTL4. Gordon Research Conferences - Lipoprotein Metabolism,. South Hadley, MA, USA. - Popeijus HE and Mensink RP
SCD-1: a role in type 2 diabetes mellitus? NuGO week 2006, Oxford, United Kingdom. - Radonjic M, van Erk M, Wopereis S, Thissen U, Willems van Dijk KV, and Müller M
The effect of high fat diets on development of metabolic syndrom inApoE3-Leiden mouse: a systems approach. Keystome symposium "Metabolic syndrome and Cardiovascular Risk", USA. - Van den Bosch H, De Wit N, Vermeulen H, Hooiveld G, Kuipers F, Müller M, and Van der Meer R
A high fat diet down-regulates gene expression of cholesterol efflux transporters in the small intestine of mice. FASEB Summer Research Conferences, Tucson, USA. - Wopereis S, Thissen U, Boeldijk I, Havekes L, Müller M, and Van Ommen B
Liver metabolomics in transgenic APOE3Leiden mice treated with different high fat diets. The Second Annual International Conference of the Metabolomics Society, Boston, U.S.A.
2005
Peer-reviewed papers
- Kaput J and Ordovas JM (2005)
The case for strategic international alliances to harness nutritional genomics for public and personal health. British Journal of Nutrition 94, 623-632 .
Invited lectures at international conferences
- Müller M
Nutrigenomics and computational biology. ILSI Nutrigenomics conference, 11-9-2005 . Singapore, Singapore. - Müller M
Polyunsaturated fatty acids and immune response. ILSI Nutrigenomics conference, 9-12-2005 . Singapore, Singapore. - Müller M
Nutrigenomics: Signals, sensors and stress signatures. NuGO Week, 13-9-2005 . Florence, Italy. - Müller M
Assessing the heatlh effects of bioactive food components. NIH conference, 24-3-2005 . Bethesda MD, USA. - Müller M
How genomics tools can help to understand liver pathology. Postgraduate course Europeanm Association for the Study of the Liver "Post-genome Medicine", 17-4-2005 . Paris, France. - Müller M
Nutrigenomics: signals, stressors and stress signatures. Zodiac, 4-10-2005 . Wageningen, The Netherlands. - Müller M
Nutrigenomics: from molecular nutrition to prevention of disease. Genomics Momentum 2005, 5-10-2005 . The Hague, The Netherlands. - Müller M
Nutrigenomics: from molecular nutrition to prevention of disease. Plant GEMS 2005, 21-9-2005 . Amsterdam, The Netherlands. - Müller M
Nutrigenomics: From molecular nutrtition to prevention of disease. NuGO conference "Personalized Nutrition", 4-11-2005 . Mallorca, Spain. - Müller M
Nutrigenomics: from molecular nutrition to prevention of disease. 50th Meeting of the Italian Society for Biochemistry, 29-9-2005 . Rimini, Italy.
Posters
- Koks PD, Van Erk MJ, Thissen U, Afman L, Van Ommen B, and Müller M
Methods for high throughput microarray data analysis of the ICN high dietary fat mouse study. NuGOweek,. Florence, Italy. - Afman LA, GrootteBromhaar MM, and Müller M
Changes in gene expression patterns during the aetiology of diet-induced insulin resistance in mice. NuGOweek. Florence, Italy. - De Wit N, Vermeulen H, Afman L, VanderMeer R, and Muller M
Microarray analysis of small intestinal gene expression modulations in C57Bl/6 mice developing metabolic syndrome on a high fat diet. NUGO Week, Florence, Italy. - Bragt MCE, Plat J, Greve JW, and Mensink RP
Relationships between gene expression profiles in PBMCS and peripheral tissues. NuGOweek Florence, Italy. - Gaj S, Evelo CTA, and Mensink RP
Effect of short-term dietary interventions on molecular signatures in man. 2nd NUGOweek, Florence, Italy.