work packages
NGC research is organised into closely interrelated work packages (WP) headed by WP leaders, who are responsible for the scientific leadership and project management of
their WP.
work package a: Intestinal and metabolic stress
task:
To Identifying human related, gut-derived biomarkers of insulin resistance syndrome (IRS) by using dietary stressed mouse models and “omics” technologies.
work package b: Liver and metabolic stress
task:
To understand fatty-acid dependent gene regulation in the liver and to identify human related, liver-derived biomarkers of insulin resistance syndrome, with a focus on the interaction between nutrient and pro-inflammatory signalling (two-hit model).
work package c: Peripheral tissues & metabolic stress
task:
To develop and validate molecular signatures of muscle and adipose tissue to predict individual dietary responsiveness.
work package d: Susceptibility genes & metabolic stress
task:
To identify genes and metabolic pathways that help the early signalling of metabolic syndrome by means of human and mouse QTL mapping.
work package e: Diet & metabolic stress – human studies
task:
To demonstrate the feasibility of human nutrigenomics and to develop and validate molecular signatures to predict individual dietary responsiveness in humans.
work package f: Data management and systems biology
task:
To provide guidance in the analysis of transcriptome data, perform metabolomics analysis and make a statistical evaluation of all the consortium’s relevant studies in order to integrate the results on a ‘systems” level.
work package integration
task:
To coordinate large-scale nutrigenomics studies by applying the NGC data analysis pipeline and to improve nutrigenomics data handling and storage.